Hepatotoxicity induced by PPⅥ and PPⅦ in zebrafish were related to the Cholesterol disorder
Z Li, Y Tang, Z Liu, Q Fan, M Chen, Z Lin, C Zhao, R Lin - Phytomedicine, 2022 - Elsevier
Abstract Background PPⅥ 2 and PPⅦ 3 were a group of Pennogenin compounds extracted
from the Paris polyphylla and caused hepatotoxicity in human, while the potential underlying
mechanism was unclear. Purpose To evaluated the adverse effects of PPⅥ and PPⅦ on the
liver in the zebrafish. Method In this study, 4dpf zebrafish were used for acute toxicity test, LC
0 was calculated, and 1/2LC 0 and 3/5LC 0 were selected for pathological section and liver
area measurement to verify the hepatotoxicity of PPⅥ and PPⅦ. Etabonomics study was …
from the Paris polyphylla and caused hepatotoxicity in human, while the potential underlying
mechanism was unclear. Purpose To evaluated the adverse effects of PPⅥ and PPⅦ on the
liver in the zebrafish. Method In this study, 4dpf zebrafish were used for acute toxicity test, LC
0 was calculated, and 1/2LC 0 and 3/5LC 0 were selected for pathological section and liver
area measurement to verify the hepatotoxicity of PPⅥ and PPⅦ. Etabonomics study was …
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