[HTML][HTML] Hesperetin modulates TGFβ induced metastatic potential of prostate cancer cells by altering histone methylation marks

N Dalpatraj, J Tak, A Naik, N Thakur - Advances in Cancer Biology …, 2022 - Elsevier
Prostate cancer is the most prevalent cancer in males, and usually, death occurs due to
bone metastasis. TGFβ has been shown to play an essential role in the metastasis of
prostate cancer cells by promoting epithelial-to-mesenchymal transition (EMT). Hesperetin is
known to possess anti-microbial, anti-fungal, antioxidant, and anti-cancer properties and
good bioavailability. Therefore, this study investigated the effect of hesperetin on TGFβ-
induced cell proliferation and EMT in prostate cancer cells (PC3). Interestingly, we found that …
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