Heterodimerization with different Jun proteins controls c-Fos intranuclear dynamics and distribution
The c-Fos proto-oncogenic transcription factor defines a multigene family controlling many
processes both at the cell and the whole organism level. To bind to its target AP-1/12-O-
tetradecanoylphorbol-13-acetate-responsive element or cAMP-responsive element DNA
sequences in gene promoters and exert its transcriptional part, c-Fos must heterodimerize
with other bZip proteins, its best studied partners being the Jun proteins (c-Jun, JunB, and
JunD). c-Fos expression is regulated at many transcriptional and post-transcriptional levels …
processes both at the cell and the whole organism level. To bind to its target AP-1/12-O-
tetradecanoylphorbol-13-acetate-responsive element or cAMP-responsive element DNA
sequences in gene promoters and exert its transcriptional part, c-Fos must heterodimerize
with other bZip proteins, its best studied partners being the Jun proteins (c-Jun, JunB, and
JunD). c-Fos expression is regulated at many transcriptional and post-transcriptional levels …
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