High‐Contrast Fluorescence Imaging of Tumors In Vivo Using Nanoparticles of Amphiphilic Brush‐Like Copolymers Produced by ROMP
K Miki, A Kimura, K Oride, Y Kuramochi… - Angewandte Chemie …, 2011 - Wiley Online Library
Angewandte Chemie International Edition, 2011•Wiley Online Library
Nanoparticles at work: High‐contrast tumor imaging of mice was performed by using
copolymers with hydrophobic and hydrophilic polymer brushes that form cross‐linked
assemblies and show a highly stable core surface in aqueous media (see picture). Cyclic
RGD peptides and glucosamine moieties were localized on the surface of the assemblies
and acted as targeting agents (TA) that enhanced the accumulation of the assemblies in
tumor tissues.
copolymers with hydrophobic and hydrophilic polymer brushes that form cross‐linked
assemblies and show a highly stable core surface in aqueous media (see picture). Cyclic
RGD peptides and glucosamine moieties were localized on the surface of the assemblies
and acted as targeting agents (TA) that enhanced the accumulation of the assemblies in
tumor tissues.
Abstract
Nanoparticles at work: High‐contrast tumor imaging of mice was performed by using copolymers with hydrophobic and hydrophilic polymer brushes that form cross‐linked assemblies and show a highly stable core surface in aqueous media (see picture). Cyclic RGD peptides and glucosamine moieties were localized on the surface of the assemblies and acted as targeting agents (TA) that enhanced the accumulation of the assemblies in tumor tissues.
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