High dose (4 mg/kg/day) versus usual dose (2 mg/kg/day) oral prednisolone for treatment of infantile spasms: an open-label, randomized controlled trial
P Chellamuthu, S Sharma, P Jain, JS Kaushik, A Seth… - Epilepsy research, 2014 - Elsevier
Objectives This study aimed to test the hypothesis that high-dose prednisolone (4
mg/kg/day) may be more efficacious than usual-dose (2 mg/kg/day) prednisolone for spasm
resolution at 14-days in children with infantile spasms. Methods This was a randomized,
open-label-trial conducted at a tertiary-level-hospital from February-2012 to March-2013.
Children aged 3-months to 2-years presenting with infantile spasms in clusters (at least 1
cluster/day) with hypsarrhythmia or its variants on EEG were enrolled. The study participants …
mg/kg/day) may be more efficacious than usual-dose (2 mg/kg/day) prednisolone for spasm
resolution at 14-days in children with infantile spasms. Methods This was a randomized,
open-label-trial conducted at a tertiary-level-hospital from February-2012 to March-2013.
Children aged 3-months to 2-years presenting with infantile spasms in clusters (at least 1
cluster/day) with hypsarrhythmia or its variants on EEG were enrolled. The study participants …
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