High-dose chemotherapy followed by autologous stem cell transplantation as first-line therapy in aggressive non-Hodgkin's lymphoma: a meta-analysis

J Strehl, U Mey, A Glasmacher, B Djulbegovic… - …, 2003 - haematologica.org
BACKGROUND AND OBJECTIVES: High-dose chemotherapy followed by autologous stem
cell transplantation (HDT/ASCT) has proven to be superior to conventional chemotherapy in
patients with chemosensitive relapse of aggressive non-Hodgkin's lymphoma (NHL).
Therefore, HDT/ASCT was evaluated as part of first-line therapy. Several trials generated
conflicting results. This meta-analysis summarizes the available evidence from all suitable
studies. DESIGN AND METHODS: Prospective, randomized trials with HDT/ASCT as first …

High-dose chemotherapy followed by autologous stem cell transplantation as a first-line therapy for high-risk primary breast cancer: a meta-analysis

J Wang, Q Zhang, R Zhou, B Chen, J Ouyang - PLoS One, 2012 - journals.plos.org
Background and Objectives Several trials have generated conflicting results about the
results of high-dose chemotherapy followed by autologous stem cell transplantation (HDCT)
for primary breast cancer. This meta-analysis summarizes the available evidence from all
suitable studies. Design and Methods Prospective, randomized trials with HDCT as a first-
line therapy for primary breast cancer were included in this meta-analysis. The primary
outcome of interest for our analysis was survival (disease-free survival and overall survival); …
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