[HTML][HTML] High-dose cholecalciferol reduces parathyroid hormone in patients with early chronic kidney disease: a pilot, randomized, double-blind, placebo-controlled …
Background: Vitamin D deficiency contributes to secondary hyperparathyroidism, which
occurs early in chronic kidney disease (CKD). Objectives: We aimed to determine whether
high-dose cholecalciferol supplementation for 1 y in early CKD is sufficient to maintain
optimal vitamin D status (serum 25-hydroxyvitamin D [25 (OH) D] concentration≥ 30 ng/mL)
and decrease serum parathyroid hormone (PTH). A secondary aim was to determine the
effect of cholecalciferol on blood pressure and serum fibroblast growth factor-23 (FGF23) …
occurs early in chronic kidney disease (CKD). Objectives: We aimed to determine whether
high-dose cholecalciferol supplementation for 1 y in early CKD is sufficient to maintain
optimal vitamin D status (serum 25-hydroxyvitamin D [25 (OH) D] concentration≥ 30 ng/mL)
and decrease serum parathyroid hormone (PTH). A secondary aim was to determine the
effect of cholecalciferol on blood pressure and serum fibroblast growth factor-23 (FGF23) …
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