The pulse energy and average power are two long-sought parameters of femtosecond lasers. In the fields of nonlinear-optics and strong-field physics, they respectively play the role to unlock the various nonlinear processes and provide enough photon fluxes. In this paper, a high-energy and high-power Yb:CALGO regenerative amplifier with 120 fs pulse width is reported. This high-performance regenerative amplifier can work with high stability in a large tuning range of repetition rates. Varying the repetition rate from 3 to 180 kHz, the maximum output power of 36 W and the pulse energy up to 4.3 mJ, corresponding to a peak power of more than 20 GW are demonstrated. The output beam is near diffraction limited with M^2?=?1.09 and 1.14 on the horizontal and vertical directions, respectively. In addition, multi-plate compression is employed to achieve 30 fs output with 23 W average power which is attractive for applications such as high-harmonic generation.