Hippocampal salt-inducible kinase 2 plays a role in depression via the CREB-regulated transcription coactivator 1–cAMP response element binding–brain-derived …
B Jiang, H Wang, JL Wang, YJ Wang, Q Zhu… - Biological …, 2019 - Elsevier
Background Developing novel pharmacological targets beyond monoaminergic systems is
now a popular strategy for finding new ways to treat depression. Salt-inducible kinase (SIK)
is a kinase that regulates the nuclear translocation of cyclic adenosine monophosphate
response element binding protein (CREB)-regulated transcription coactivator (CRTC) by
phosphorylation. Here, we hypothesize that dysfunction of the central SIK-CRTC system may
contribute to the pathogenesis of depression. Methods Chronic social defeat stress (CSDS) …
now a popular strategy for finding new ways to treat depression. Salt-inducible kinase (SIK)
is a kinase that regulates the nuclear translocation of cyclic adenosine monophosphate
response element binding protein (CREB)-regulated transcription coactivator (CRTC) by
phosphorylation. Here, we hypothesize that dysfunction of the central SIK-CRTC system may
contribute to the pathogenesis of depression. Methods Chronic social defeat stress (CSDS) …
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