Hippocampal sharp wave-ripples and the associated sequence replay emerge from structured synaptic interactions in a network model of area CA3
Hippocampal place cells are activated sequentially as an animal explores its environment.
These activity sequences are internally recreated ('replayed'), either in the same or reversed
order, during bursts of activity (sharp wave-ripples [SWRs]) that occur in sleep and awake
rest. SWR-associated replay is thought to be critical for the creation and maintenance of long-
term memory. In order to identify the cellular and network mechanisms of SWRs and replay,
we constructed and simulated a data-driven model of area CA3 of the hippocampus. Our …
These activity sequences are internally recreated ('replayed'), either in the same or reversed
order, during bursts of activity (sharp wave-ripples [SWRs]) that occur in sleep and awake
rest. SWR-associated replay is thought to be critical for the creation and maintenance of long-
term memory. In order to identify the cellular and network mechanisms of SWRs and replay,
we constructed and simulated a data-driven model of area CA3 of the hippocampus. Our …
[PDF][PDF] Hippocampal sharp wave-ripples and the associated sequence replay emerge from structured synaptic interactions in a network model of area CA3
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Abstract 1 Hippocampal place cells are activated sequentially as an animal explores its
environment. 2 These activity sequences are internally recreated (“replayed”), either in the
same or re-3 versed order, during bursts of activity (sharp wave-ripples; SWRs) that occur in
sleep and 4 awake rest. SWR-associated replay is thought to be critical for the creation and
main-5 tenance of long-term memory. In order to identify the cellular and network
mechanisms 6 of SWRs and replay, we constructed and simulated a data-driven model of …
environment. 2 These activity sequences are internally recreated (“replayed”), either in the
same or re-3 versed order, during bursts of activity (sharp wave-ripples; SWRs) that occur in
sleep and 4 awake rest. SWR-associated replay is thought to be critical for the creation and
main-5 tenance of long-term memory. In order to identify the cellular and network
mechanisms 6 of SWRs and replay, we constructed and simulated a data-driven model of …
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