… Post-translational modification of histones provides an important … histone modifications
observed in cancer, and discuss how these epigenetic changes, caused by alterations in histone-…

… To describe these modifications of histones, new terminology that is linked to cancer is
introduced as histone onco -modifications [16]. Among these modifications, histone acetylation at …

… We focus mainly on post-translational histone modifications since they are one of the major
epigenetic mechanisms regulating gene expression and when they are imbalanced this can …

… histone genes within the histone cluster 1, histone cluster 2, histone cluster 3 and histone 4
… The genes belonging to the histone H1 family are indicated in purple, the genes of the H2A …

… , acetylation, and ubiquitylation of histones. We have shown how … histones in developing
cancer. We have also discussed various histone modifiers and their role in manipulating histone …

… DNA wrapped around a histone octamer core consisting of histone H3–H4 tetramer and two
copies of histone H2A–H2B dimers. Adjacent linker histones such as histone H1 can further …

… methylation and modification of histones and non-histone proteins lead to … histone H3
lysine 4 (K4me3) and acetylated histone H3 lysine 9 (K9ac) [2], [5]. Alterations in these histone …

… of histone epigenetic modifications in lung cancer cell lines. The treatment of low E-cadherin
lung cancer cell lines with histone … revealed that the histone hypoacetylation levels correlate …

… histones with high-frequency point mutations that are associated with tumorigenesis. Although
each histone … to have a dominant effect over global histone H3 methylation level at the …

… Thus, our results indicate that histone onco-modifications are … Remarkably, in PCa,
histone onco-modifications herald CpG … that CpG methylation precedes histone onco-modifications. …