Homogeneous hydroxyapatite/alginate composite hydrogel promotes calcified cartilage matrix deposition with potential for three-dimensional bioprinting
Calcified cartilage regeneration plays an important role in successful osteochondral repair,
since it provides a biological and mechanical transition from the unmineralized cartilage at
the articulating surface to the underlying mineralized bone. To biomimic native calcified
cartilage in engineered constructs, here we test the hypothesis that hydroxyapatite (HAP)
stimulates chondrocytes to secrete the characteristic matrix of calcified cartilage. Sodium
citrate (SC) was added as a dispersant of HAP within alginate (ALG), and homogeneous …
since it provides a biological and mechanical transition from the unmineralized cartilage at
the articulating surface to the underlying mineralized bone. To biomimic native calcified
cartilage in engineered constructs, here we test the hypothesis that hydroxyapatite (HAP)
stimulates chondrocytes to secrete the characteristic matrix of calcified cartilage. Sodium
citrate (SC) was added as a dispersant of HAP within alginate (ALG), and homogeneous …
以上显示的是最相近的搜索结果。 查看全部搜索结果