Hydrogen sulfide: a novel nephroprotectant against cisplatin-induced renal toxicity
GJ Dugbartey, HR Bouma, I Lobb, A Sener - Nitric Oxide, 2016 - Elsevier
Cisplatin is a potent chemotherapeutic agent for the treatment of various solid-organ
cancers. However, a plethora of evidence indicates that nephrotoxicity is a major side effect
of cisplatin therapy. While the antineoplastic action of cisplatin is due to formation of cisplatin-
DNA cross-links, which damage rapidly dividing cancer cells upon binding to DNA, its
nephrotoxic effect results from metabolic conversion of cisplatin into a nephrotoxin and
production of reactive oxygen species, causing oxidative stress leading to renal tissue injury …
cancers. However, a plethora of evidence indicates that nephrotoxicity is a major side effect
of cisplatin therapy. While the antineoplastic action of cisplatin is due to formation of cisplatin-
DNA cross-links, which damage rapidly dividing cancer cells upon binding to DNA, its
nephrotoxic effect results from metabolic conversion of cisplatin into a nephrotoxin and
production of reactive oxygen species, causing oxidative stress leading to renal tissue injury …
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