… leads to increased expression of VEGF, IL-6, and CSC signature genes Nanog, Oct4 and
EZH2 consistent with increased cell … increased expression of miR-21 and miR-210 in human …

… correlated to lowered expression of total K-ras protein [27]. As … pancreatic tumor cell
metabolism may lead to a better understanding of the development and progression of this cancer. …

… The current study initially confirmed that hypoxia induced an increased number of invading
CD133+ cancer cells, hypoxic cells themselves expressed CD133 in vitro, and that CD133+ …

… Pancreatic cancer is a leading cause of cancer-related … The biologic aggressiveness of
pancreatic cancer is defined … identified hypoxia-induced expression of SOX9 in the LMET cells, …

… correlation between HIF-1 expression and pancreatic cancer aggressiveness, which in fact
… in the mechanism of hypoxia-induced invasiveness of pancreatic cancer cells. These include …

… , constitutively activated NF-κB regulates the expression of multiple … NF-κB can also induce
expression of antiapoptotic proteins … Hypoxia-induced Akt activation in PC12 cells can be …

… MUC4 expression in PC, and also provided evidence for a novel regulatory mechanism, which
leads to MUC4 degradation due to hypoxia-induced … in PC survival, aggressiveness, drug …

… aggressiveness in pancreatic cancer and … hypoxia-induced PSC activation, pancreatic
cancer cell invasion, and apoptosis by inhibiting hypoxia-inducible factor 1α (HIF-1α) expression. …

… repressed PC cell proliferation, migration, aggressiveness and tumor formation. It … expression
of HIF-1α increased RER1 expression, demonstrating that the hypoxia-induced PC cell …

… However, we also found increased expression of genes involved in cell survival (eg, Bcl-2, …
development of hypoxia to biological aggression in pancreatic cancer patients. Elucidation of …