[HTML][HTML] Hypoxia promotes the metastasis of pancreatic cancer through regulating NOX4/KDM5A-mediated histone methylation modification changes in a HIF1A …

H Li, C Peng, C Zhu, S Nie, X Qian, Z Shi, M Shi… - Clinical …, 2021 - Springer
… -related genes. We got 30 highly expressed hypoxia-related genes in pancreatic cancer
hypoxia-induced EMT phenotype. Indeed, H2O2 activated an EMT program in HAPC and Panc1 …

[PDF][PDF] … -1 (HIF-1) in Pancreatic Cancer Cell Aggressiveness and Therapeutic Resistance and the Potential Role for Pancreatic Endocrine Cells in Islet Transplantation

贾晓晖 - 2014 - core.ac.uk
… in pancreatic cancer patients may facilitate cancer cells to … -1α and thereby increase cancer
cell aggressiveness. In order to … the expression of hypoxia-induced HIF-1α was increased by …

Hypoxia enhances the interaction between pancreatic stellate cells and cancer cells via increased secretion of connective tissue growth factor

D Eguchi, N Ikenaga, K Ohuchida, S Kozono… - Journal of Surgical …, 2013 - Elsevier
… is a major factor in promoting PC aggressiveness [12]. … The aim of this study was to investigate
hypoxia-induced or … α-SMA + stromal cells within pancreatic cancer expressed a hypoxic …

α-Mangostin inhibits hypoxia-driven ROS-induced PSC activation and pancreatic cancer cell invasion

J Lei, X Huo, W Duan, Q Xu, R Li, J Ma, X Li, L Han… - Cancer letters, 2014 - Elsevier
… hypoxia in pancreatic cancer aggressiveness, and … hypoxia-induced PSC activation and
pancreatic cancer cell invasion through the inhibition of HIF-1α stabilization and GLI1 expression

Hypoxia: Friend or Foe for drug delivery in Pancreatic Cancer

VM Shah, BC Sheppard, RC Sears, AWG Alani - Cancer letters, 2020 - Elsevier
… Therefore, hypoxia induced cellular pathways which trigger … inhibit HIF1α expression in
human pancreatic cancer cells by … its progression and aggressiveness, the contribution of tumor

Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic

Q Shi, JL Abbruzzese, S Huang, IJ Fidler, Q Xiong… - Clinical Cancer …, 1999 - AACR
… pH, influence IL-8 expression, thereby contributing to the aggressiveness of human …
Norris ML, Millhorn DE Hypoxia-induced protein binding to O 2 -responsive sequences on …

… cytotoxin, TX-2098 has antitumor effect in pancreatic cancer; possible mechanism through inhibiting VEGF and hypoxia inducible factor-1α targeted gene expression

K Miyake, M Nishioka, S Imura, E Batmunkh… - Experimental cell …, 2012 - Elsevier
tumor cells and high interstitial pressure. Indeed, hypoxia has been negatively correlated with
various indicators of tumor aggression… of hypoxia-induced angiogenic factors in tumor cells

Mechanism of miR-210 involved in epithelial–mesenchymal transition of pancreatic cancer cells under hypoxia

J Ni, S Zhou, W Yuan, F Cen, Q Yan - Journal of Receptors and …, 2019 - Taylor & Francis
… In this study, hypoxia-induced EMT process in pancreatic cancer cells, HIF-1α, and NF-κB
expression was increased ( Figures 1(c) and 4(e) ), confirming that the NF-κB signaling …

Hypoxia-induced snail expression through transcriptional regulation by HIF-1α in pancreatic cancer cells

G Zhu, C Huang, Z Feng, X Lv, Z Qiu - Digestive diseases and sciences, 2013 - Springer
… to detect phenotypic changes of pancreatic cancer cells under normoxic and hypoxic … to
detect gene expression in pancreatic cancer cell lines and tissues or normal pancreatic tissues. …

… mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through posttranscriptional regulation of the proto-oncogene PIM1 in pancreatic cancer cells

FF Blanco, M Jimbo, J Wulfkuhle, I Gallagher, J Deng… - Oncogene, 2016 - nature.com
… of PIM1 expression to chemoresistance was determined in a panel of seven PDA cells
lines where hypoxia induced PIM1 expression … if PIM1 expression contributed to hypoxia-induced