IL-1-dependent enteric gliosis guides intestinal inflammation and dysmotility and modulates macrophage function

R Schneider, P Leven, S Mallesh, M Breßer… - Communications …, 2022 - nature.com
intestinal inflammation after abdominal surgery Finally, we validated the existence of IL-1-dependent
enteric gliosis … from patients undergoing open abdominal surgery for pancreatic …

Mini-Review: Enteric Glial Cell Reactions to Inflammation and Potential Therapeutic Implications for GI Diseases, Motility Disorders and Abdominal Pain

A Linan-Rico, F Ochoa-Cortes, R Schneider… - Neuroscience …, 2023 - Elsevier
… mechanism of enteric gliosis in POI. In this regard, a recent study has shown that IL-1-dependent
enteric gliosis guides intestinal inflammation and dysmotility and modulates the …

The role of reactive enteric glia‐macrophage interactions in acute and chronic inflammation

S Reiner, S Linda, H Ebrahim… - … & Motility, 2024 - Wiley Online Library
… A novel P2X2- dependent purinergic mechanism of enteric gliosis in intestinal inflammation
IL- 1- dependent enteric gliosis guides intestinal inflammation and dysmotility and modulates

Enteric Nervous System Alterations in Inflammatory Bowel Disease: Perspectives and Implications

S Suman - Gastrointestinal Disorders, 2024 - mdpi.com
… role of these changes in persistent GI inflammation and the recurrence of IBD. Finally, we …
IL-1-dependent enteric gliosis guides intestinal inflammation and dysmotility and modulates

From diversity to disease: unravelling the role of enteric glial cells

S Santhosh, L Zanoletti, LA Stamp, MM Hao… - Frontiers in …, 2024 - frontiersin.org
Enteric gliosis is also part of an intestinal immune response … is known to modulate intestinal
homeostasis, inflammation, and … shown that the enteric neuronal network guides tumour cell …

The Physiology of Enteric Glia

J Gonzales, BD Gulbransen - Annual Review of Physiology, 2024 - annualreviews.org
… in modulating neural pathways that control gut motility and … of inflammation and guide their
differentiation toward an anti-… of enteric gliosis in intestinal inflammation. EMBO Mol. Med. …

IL-1R signaling drives enteric glia-macrophage interactions in colorectal cancer

L van Baarle, V De Simone, L Schneider… - Nature …, 2024 - nature.com
enteric glia modulate immune responses in other intestinal … underscoring the IL-1-dependent
interaction between EGCs … studied in the context of intestinal inflammation 17,37 . However, …

Gpr37 modulates the severity of inflammation-induced GI dysmotility by regulating enteric reactive gliosis.

K Robertson, O Hahn, BG Robinson, AT Faruk… - bioRxiv, 2024 - biorxiv.org
… We show that Gpr37 contributes to key components of LPS-induced reactive gliosis including
… Gpr37 contributes to inflammation- 85 induced GI dysmotility by regulating reactive gliosis. …

β-adrenergic signaling triggers enteric glial reactivity and acute enteric gliosis during surgery

P Leven, R Schneider, L Schneider, S Mallesh… - Journal of …, 2023 - Springer
… a motility disorder and common complication after abdominal … in POI and other intestinal
inflammation-driven diseases [26]. … Acute enteric gliosis is modulated by sympathetic innervation…

Macrophage-induced enteric neurodegeneration leads to motility impairment during gut inflammation

M Breßer, KD Siemens, L Schneider… - EMBO Molecular …, 2025 - embopress.org
… , modulate neuroimmune processes in the gut after … and acute intestinal inflammation
activate enteric neurons and … This enteric neuron–macrophage interaction in gut inflammation