Preeclampsia is a complex disease of pregnancy with both feto-placental and maternal
factors contributing to its pathogenesis. Failed transformation of the uterine spiral arteries
leading to release of ischemic placental factors into the maternal circulation is thought to be
the initial step in triggering preeclampsia. One placental factor associated with preeclampsia
is necrotic trophoblastic debris that is deported in the maternal blood. The deported material
ranges from multinucleated syncytial knots to nano-meter scale exosomes. Increasingly, it is …