IMPLEMENTATION OF CORONARY ARTERY PHANTOM WITH ARTIFICIAL HYPEREMIA AND ANALYSIS OF PRESSURE AND FLOW VELOCITY DEPENDING ON …
Journal of the American College of Cardiology, 2019•jacc.org
Background Fractional Flow Reserve (FFR) and instantaneous wave-Free Ratio (iFR) are
the two most commonly used coronary pressure based indices of physiological stenosis
severity. The goals of this study are to estimate the differential power of the resting pd/pa,
FFR, and iFR in an experiment system implementing artificial hyperemia and to confirm the
possibility of calculating the wedge pressure. Methods The experiment setups were three
conditions as follows: first, forward and backward flow, second, only forward flow and third …
the two most commonly used coronary pressure based indices of physiological stenosis
severity. The goals of this study are to estimate the differential power of the resting pd/pa,
FFR, and iFR in an experiment system implementing artificial hyperemia and to confirm the
possibility of calculating the wedge pressure. Methods The experiment setups were three
conditions as follows: first, forward and backward flow, second, only forward flow and third …
Background
Fractional Flow Reserve (FFR) and instantaneous wave-Free Ratio (iFR) are the two most commonly used coronary pressure based indices of physiological stenosis severity. The goals of this study are to estimate the differential power of the resting pd/pa, FFR, and iFR in an experiment system implementing artificial hyperemia and to confirm the possibility of calculating the wedge pressure.
Methods
The experiment setups were three conditions as follows: first, forward and backward flow, second, only forward flow and third, only backward flow. Artificial hyperemia was defined as a lower hydrostatic pressure in the second condition. Assumed FFR (aFFR) was measured in artificial hyperemia. Assumed iFR (aiFR) was measured at the higher hydrostatic pressure and the second condition. Three kinds of stenosis (49, 71 and 88%) models were used. Forward and backward pressures were separated by wave separate analysis.
Results
According to the degree of stenosis, the ratios of increase in flow when transitioning from the first to the second condition at lower hydrostatic pressure were 2.1, 1.6, and 1.1. Resting Pd/Pa were 1.00, 0.96 and 0.67, aiFR 0.91, 0.88, and 0.60 and aFFR 0.81, 0.64, and 0.46, as shown in Fig. 1. The correlation between artificial wedge pressure and calculated wedge pressure was high (rho= 0.990, p< 0.0001).
Conclusion
The differential power for evaluation of stenosis severity is strong in order of aFFR, aiFR and resting Pd/Pa in our study. And the wedge pressure could be calculated.
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