INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication
U Dixit, S Bhutoria, X Wu, L Qiu, M Spira… - Nature …, 2021 - nature.com
Abstract INI1/SMARCB1 binds to HIV-1 integrase (IN) through its Rpt1 domain and exhibits
multifaceted role in HIV-1 replication. Determining the NMR structure of INI1-Rpt1 and
modeling its interaction with the IN-C-terminal domain (IN-CTD) reveal that INI1-Rpt1/IN-
CTD interface residues overlap with those required for IN/RNA interaction. Mutational
analyses validate our model and indicate that the same IN residues are involved in both INI1
and RNA binding. INI1-Rpt1 and TAR RNA compete with each other for IN binding with …
multifaceted role in HIV-1 replication. Determining the NMR structure of INI1-Rpt1 and
modeling its interaction with the IN-C-terminal domain (IN-CTD) reveal that INI1-Rpt1/IN-
CTD interface residues overlap with those required for IN/RNA interaction. Mutational
analyses validate our model and indicate that the same IN residues are involved in both INI1
and RNA binding. INI1-Rpt1 and TAR RNA compete with each other for IN binding with …
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