Identification and description of a novel murine model for polytrauma and shock
LF Gentile, DC Nacionales, AG Cuenca… - Critical care …, 2013 - journals.lww.com
Objective: To develop a novel polytrauma model that better recapitulates the immunologic
response of the severely injured patient by combining long-bone fracture, muscle tissue
damage, and cecectomy with hemorrhagic shock, resulting in an equivalent Injury Severity
Score of greater than 15. We compared this new polytrauma/shock model to historically
used murine trauma-hemorrhage models. Design: Pre-clinical controlled in vivo laboratory
study. Setting: Laboratory of Inflammation Biology and Surgical Science. Subjects: Six-to 10 …
response of the severely injured patient by combining long-bone fracture, muscle tissue
damage, and cecectomy with hemorrhagic shock, resulting in an equivalent Injury Severity
Score of greater than 15. We compared this new polytrauma/shock model to historically
used murine trauma-hemorrhage models. Design: Pre-clinical controlled in vivo laboratory
study. Setting: Laboratory of Inflammation Biology and Surgical Science. Subjects: Six-to 10 …
以上显示的是最相近的搜索结果。 查看全部搜索结果