[HTML][HTML] Identification of a B cell-dependent subpopulation of multiple sclerosis by measurements of brain-reactive B cells in the blood
S Kuerten, G Pommerschein, SK Barth, C Hohmann… - Clinical …, 2014 - Elsevier
B cells are increasingly coming into play in the pathogenesis of multiple sclerosis (MS).
Here, we screened peripheral blood mononuclear cells (PBMC) from patients with clinically
isolated syndrome (CIS), MS, other non-inflammatory neurological, inflammatory
neurological or autoimmune diseases, and healthy donors for their B cell reactivity to CNS
antigen using the enzyme-linked immunospot technique (ELISPOT) after 96 h of polyclonal
stimulation. Our data show that nine of 15 patients with CIS (60.0%) and 53 of 67 patients …
Here, we screened peripheral blood mononuclear cells (PBMC) from patients with clinically
isolated syndrome (CIS), MS, other non-inflammatory neurological, inflammatory
neurological or autoimmune diseases, and healthy donors for their B cell reactivity to CNS
antigen using the enzyme-linked immunospot technique (ELISPOT) after 96 h of polyclonal
stimulation. Our data show that nine of 15 patients with CIS (60.0%) and 53 of 67 patients …
以上显示的是最相近的搜索结果。 查看全部搜索结果