Identification of potential drug targets in Yersinia pestis using metabolic pathway analysis: MurE ligase as a case study

A Sharma, A Pan - European journal of medicinal chemistry, 2012 - Elsevier
Sporadic outbreaks of plague, lack of a vaccine, emergence of multidrug-resistant strains of
Yersinia pestis, and its potential use in bioterrorism, call for an urgent need to develop new
drugs for plague. We have used comparative metabolic pathway analysis to identify 245
drug-target candidate enzymes in Y. pestis CO92 which are non-homologous to host Homo
sapiens and likely to be essential for the pathogen's survival. Further analysis revealed that
25 of these are potential choke point enzymes. As a case study, structure of a choke point …

Identification of potential drug targets in Yersinia pestis using metabolic pathway analysis: MurE ligase as a case study.

AS Aditya Sharma, AP Archana Pan - 2012 - cabidigitallibrary.org
Sporadic outbreaks of plague, lack of a vaccine, emergence of multidrug-resistant strains of
Yersinia pestis, and its potential use in bioterrorism, call for an urgent need to develop new
drugs for plague. We have used comparative metabolic pathway analysis to identify 245
drug-target candidate enzymes in Y. pestis CO92 which are non-homologous to host Homo
sapiens and likely to be essential for the pathogen's survival. Further analysis revealed that
25 of these are potential choke point enzymes. As a case study, structure of a choke point …
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