Cochlear implantation is currently the treatment of choice for children with severe to
profound hearing impairment. However, the outcomes with cochlear implants (CIs) vary
significantly among recipients. The purpose of the present study is to identify the genetic
determinants of poor CI outcomes. Twelve children with poor CI outcomes (the “cases”) and
30 “matched controls” with good CI outcomes were subjected to comprehensive genetic
analyses using massively parallel sequencing, which targeted 129 known deafness genes …