Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes
SF Liao, CH Liang, MY Ho, TL Hsu… - Proceedings of the …, 2013 - National Acad Sciences
Carbohydrate-based vaccines have shown therapeutic efficacy for infectious disease and
cancer. The mushroom Ganoderma lucidum (Reishi) containing complex polysaccharides
has been used as antitumor supplement, but the mechanism of immune response has rarely
been studied. Here, we show that the mice immunized with a l-fucose (Fuc)-enriched Reishi
polysaccharide fraction (designated as FMS) induce antibodies against murine Lewis lung
carcinoma cells, with increased antibody-mediated cytotoxicity and reduced production of …
cancer. The mushroom Ganoderma lucidum (Reishi) containing complex polysaccharides
has been used as antitumor supplement, but the mechanism of immune response has rarely
been studied. Here, we show that the mice immunized with a l-fucose (Fuc)-enriched Reishi
polysaccharide fraction (designated as FMS) induce antibodies against murine Lewis lung
carcinoma cells, with increased antibody-mediated cytotoxicity and reduced production of …
Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes.
LSF Liao ShihFen, LCH Liang ChiHui, HMY Ho MingYi… - 2013 - cabidigitallibrary.org
Carbohydrate-based vaccines have shown therapeutic efficacy for infectious disease and
cancer. The mushroom Ganoderma lucidum (Reishi) containing complex polysaccharides
has been used as antitumor supplement, but the mechanism of immune response has rarely
been studied. Here, we show that the mice immunized with a l-fucose (Fuc)-enriched Reishi
polysaccharide fraction (designated as FMS) induce antibodies against murine Lewis lung
carcinoma cells, with increased antibody-mediated cytotoxicity and reduced production of …
cancer. The mushroom Ganoderma lucidum (Reishi) containing complex polysaccharides
has been used as antitumor supplement, but the mechanism of immune response has rarely
been studied. Here, we show that the mice immunized with a l-fucose (Fuc)-enriched Reishi
polysaccharide fraction (designated as FMS) induce antibodies against murine Lewis lung
carcinoma cells, with increased antibody-mediated cytotoxicity and reduced production of …
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