Immunogenicity in protein and peptide based-therapeutics: an overview
L Fernandez, RH Bustos, C Zapata… - Current Protein and …, 2018 - ingentaconnect.com
Currently it is well known that all biological drugs, including those with a fully human
structure, are capable of inducing a host immune response known as immunogenicity [1].
The presence of ADAs can condition the drug´ s level and action, thus modifying the
therapeutic effect and even the safety profile by its mechanism of action-neutralizing or non-
neutralizing-and/or an increase in its clearance. Immunogenicity is a dynamic factor to be
taken into account in biological therapy, especially in long-term treatments, and as a …
structure, are capable of inducing a host immune response known as immunogenicity [1].
The presence of ADAs can condition the drug´ s level and action, thus modifying the
therapeutic effect and even the safety profile by its mechanism of action-neutralizing or non-
neutralizing-and/or an increase in its clearance. Immunogenicity is a dynamic factor to be
taken into account in biological therapy, especially in long-term treatments, and as a …
Immunogenicity in protein and peptide based-therapeutics: An overview
L Fernandez Rodriguez, H Bustos, J Garcia, CD Zapata - intellectum.unisabana.edu.co
Currently it is well known that all biological drugs, including those with a fully human
structure, are capable of inducing a host immune response known as immunogenicity [1].
The presence of ADAs can condition the drug´ s level and action, thus modifying the
therapeutic effect and even the safety profile by its mechanism of action-neutralizing or non-
neutralizing-and/or an increase in its clearance. Immunogenicity is a dynamic factor to be
taken into account in biological therapy, especially in long-term treatments, and as a …
structure, are capable of inducing a host immune response known as immunogenicity [1].
The presence of ADAs can condition the drug´ s level and action, thus modifying the
therapeutic effect and even the safety profile by its mechanism of action-neutralizing or non-
neutralizing-and/or an increase in its clearance. Immunogenicity is a dynamic factor to be
taken into account in biological therapy, especially in long-term treatments, and as a …
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