Impact of counterbalance between macrophage migration inhibitory factor and its inhibitor Gremlin-1 in patients with coronary artery disease
II Müller, KAL Müller, A Karathanos, H Schönleber… - Atherosclerosis, 2014 - Elsevier
Objective: Monocyte infiltration is a critical step in the pathophysiology of plaque instability in
coronary artery disease (CAD). Macrophage migration inhibitory factor (MIF) is involved in
atherosclerotic plaque progression and instability leading to intracoronary thrombosis.
Gremlin-1 (Grem1) has been recently identified as endogenous inhibitor of MIF. To date
there are no data on the clinical impact of this interaction in cardiovascular patients. Methods
and results: Plasma levels of MIF and Grem1 were determined by enzyme-linked …
coronary artery disease (CAD). Macrophage migration inhibitory factor (MIF) is involved in
atherosclerotic plaque progression and instability leading to intracoronary thrombosis.
Gremlin-1 (Grem1) has been recently identified as endogenous inhibitor of MIF. To date
there are no data on the clinical impact of this interaction in cardiovascular patients. Methods
and results: Plasma levels of MIF and Grem1 were determined by enzyme-linked …
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