Impact of novel oncolytic virus HF10 on cellular components of the tumor microenviroment in patients with recurrent breast cancer
Oncolytic viruses are a promising method of cancer therapy, even for advanced
malignancies. HF10, a spontaneously mutated herpes simplex type 1, is a potent oncolytic
agent. The interaction of oncolytic herpes viruses with the tumor microenvironment has not
been well characterized. We injected HF10 into tumors of patients with recurrent breast
carcinoma, and sought to determine its effects on the tumor microenvironment. Six patients
with recurrent breast cancer were recruited to the study. Tumors were divided into two …
malignancies. HF10, a spontaneously mutated herpes simplex type 1, is a potent oncolytic
agent. The interaction of oncolytic herpes viruses with the tumor microenvironment has not
been well characterized. We injected HF10 into tumors of patients with recurrent breast
carcinoma, and sought to determine its effects on the tumor microenvironment. Six patients
with recurrent breast cancer were recruited to the study. Tumors were divided into two …
[PDF][PDF] IMPACT OF NOVEL ONCOLYTIC VIRUS HF10 ON CELLULAR COMPONENTS OF THE TUMOR MICROENVIROMENT IN PATIENTS WITH RECURRENT …
H KASUYA, N NOMURA, T SHIKANO, T FUJII… - nagoya.repo.nii.ac.jp
Oncolytic viruses are a promising method of cancer therapy, even for advanced
malignancies. HF10, a spontaneously mutated herpes simplex type 1, is a potent oncolytic
agent. The interaction of oncolytic herpes viruses with the tumor microenvironment has not
been well characterized. We injected HF10 into tumors of patients with recurrent breast
carcinoma, and sought to determine its effects on the tumor microenvironment. Six patients
with recurrent breast cancer were recruited to the study. Tumors were divided into two …
malignancies. HF10, a spontaneously mutated herpes simplex type 1, is a potent oncolytic
agent. The interaction of oncolytic herpes viruses with the tumor microenvironment has not
been well characterized. We injected HF10 into tumors of patients with recurrent breast
carcinoma, and sought to determine its effects on the tumor microenvironment. Six patients
with recurrent breast cancer were recruited to the study. Tumors were divided into two …
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