Implication of porins in β-lactam resistance of Providencia stuartii
QT Tran, KR Mahendran, E Hajjar, M Ceccarelli… - Journal of Biological …, 2010 - ASBMB
An integrative approach combining biophysical and microbiological methods was used to
characterize the antibiotic translocation through the outer membrane of Providencia stuartii.
Two novel members of the General Bacterial Porin family of Enterobacteriaceae, named
OmpPst1 and OmpPst2, were identified in P. stuartii. In the presence of ertapenem (ERT),
cefepime (FEP), and cefoxitin (FOX) in growth media, several resistant derivatives of P.
stuartii ATCC 29914 showed OmpPst1-deficiency. These porin-deficient strains showed …
characterize the antibiotic translocation through the outer membrane of Providencia stuartii.
Two novel members of the General Bacterial Porin family of Enterobacteriaceae, named
OmpPst1 and OmpPst2, were identified in P. stuartii. In the presence of ertapenem (ERT),
cefepime (FEP), and cefoxitin (FOX) in growth media, several resistant derivatives of P.
stuartii ATCC 29914 showed OmpPst1-deficiency. These porin-deficient strains showed …
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