Dietary restriction (DR) decreases body weight, improves health, and extends lifespan. DR
can be achieved by controlling how much and/or when food is provided, as well as by
adjusting nutritional composition. Because these factors are often combined during DR, it is
unclear which are necessary for beneficial effects. Several drugs have been utilized that
target nutrient-sensing gene pathways, many of which change expression throughout the
day, suggesting that the timing of drug administration is critical. Here, we discuss how …