Improved tracking and quantification of SPIO-labeled cells using bSSFP with compressed sensing TurboSPI
Understanding immune cell behaviour is important for evaluating therapeutic response in
pre-clinical models. We monitor cell migration in a mouse model of cervical cancer by
labeling cells with superparamagnetic iron oxide (SPIO). Simultaneous pre-clinical PET/MRI
confirmed that the balanced steady-state free precession (bSSFP) sequence lacks specificity
to SPIO-labeled cells within the tumor. We tested TurboSPI, a multi-echo single point
imaging technique with compressed sensing that provides high temporal resolution 3D R 2 …
pre-clinical models. We monitor cell migration in a mouse model of cervical cancer by
labeling cells with superparamagnetic iron oxide (SPIO). Simultaneous pre-clinical PET/MRI
confirmed that the balanced steady-state free precession (bSSFP) sequence lacks specificity
to SPIO-labeled cells within the tumor. We tested TurboSPI, a multi-echo single point
imaging technique with compressed sensing that provides high temporal resolution 3D R 2 …