In mpkCCD cells, long-term regulation of aquaporin-2 by vasopressin occurs independent of protein kinase A and CREB but may involve Epac
MLA Kortenoeven, C Trimpert… - American Journal …, 2012 - journals.physiology.org
Urine concentration involves the hormone vasopressin (AVP), which stimulates cAMP
production in renal principal cells, resulting in translocation and transcription of aquaporin-2
(AQP2) water channels, greatly increasing the water permeability, leading to a concentrated
urine. As cAMP levels decrease shortly after AVP addition, whereas AQP2 levels still
increase and are maintained for days, we investigated in the present study the mechanism
responsible for the AQP2 increase after long-term 1-desamino-8-d-arginine vasopressin …
production in renal principal cells, resulting in translocation and transcription of aquaporin-2
(AQP2) water channels, greatly increasing the water permeability, leading to a concentrated
urine. As cAMP levels decrease shortly after AVP addition, whereas AQP2 levels still
increase and are maintained for days, we investigated in the present study the mechanism
responsible for the AQP2 increase after long-term 1-desamino-8-d-arginine vasopressin …
以上显示的是最相近的搜索结果。 查看全部搜索结果