In vitro and in vivo pharmacological role of TLQP‐21, a VGF‐derived peptide, in the regulation of rat gastric motor functions
C Severini, G La Corte, G Improta… - British journal of …, 2009 - Wiley Online Library
Background and purpose: Vgf gene expression has been detected in various endocrine and
neuronal cells in the gastrointestinal tract. In this study we investigated the pharmacological
activity of different VGF‐derived peptides. Among these, TLQP‐21, corresponding to the 556–
576 fragment of the protein was the unique active peptide, and its pharmacological profile
was further studied. Experimental approach: The effects of TLQP‐21 were examined in vitro
by smooth muscle contraction in isolated preparations from the rat gastrointestinal tract and …
neuronal cells in the gastrointestinal tract. In this study we investigated the pharmacological
activity of different VGF‐derived peptides. Among these, TLQP‐21, corresponding to the 556–
576 fragment of the protein was the unique active peptide, and its pharmacological profile
was further studied. Experimental approach: The effects of TLQP‐21 were examined in vitro
by smooth muscle contraction in isolated preparations from the rat gastrointestinal tract and …
In vitro and in vivo pharmacological role of TLQP-21, a VGF-derived peptide, in the regulation of rat motor gastric functions
C Petrella, S Agostini, G Improta… - BRITISH JOURNAL …, 2009 - iris.uniroma1.it
Background and purpose: Vgf gene expression has been detected in various endocrine and
neuronal cells in the gastrointestinal tract. In this study we investigated the pharmacological
activity of different VGF-derived peptides. Among these, TLQP-21, corresponding to the 556-
576 fragment of the protein was the unique active peptide, and its pharmacological profile
was further studied. In vitro and in vivo pharmacological role of TLQP-21, a VGF-derived
peptide, in the regulation of rat motor gastric functions/Petrella, Carla; Agostini, Simona; …
neuronal cells in the gastrointestinal tract. In this study we investigated the pharmacological
activity of different VGF-derived peptides. Among these, TLQP-21, corresponding to the 556-
576 fragment of the protein was the unique active peptide, and its pharmacological profile
was further studied. In vitro and in vivo pharmacological role of TLQP-21, a VGF-derived
peptide, in the regulation of rat motor gastric functions/Petrella, Carla; Agostini, Simona; …
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