Introduction Amino-bisphosphonates are potent activators of human γδ T cells. The aim of
our study was to evaluate the immunomodulating properties of a single-dose of zoledronic
acid (ZA) on γδ T cells in a select group of disease-free breast cancer patients with
osteopenia. Materials and methods Blood samples were obtained, from 23 patients, before
and 7, 28, 56, 90 and 180 days after a single-dose (4 mg) of ZA and analyzed by flow
cyometry. Results A significant decrease of the different γδ T cell subsets was observed …

Results a significant decrease of Naïve Vδ2 T lymphocytes after 180 days (p< 0, 01) and a
significant progressive decrease of Central Memory subset after 28 (p< 0, 05), 90 (p< 0, 01)
and 180 days (p< 0, 01) were observed. ZA induced also a significant reduction of Effector
Memory Vδ2 T lymphocytes after 56 (p< 0, 01) and 90 days (p< 0, 05). Moreover, we
observed that patients could be divided in two groups, according to γ/δ T lymphocyte
kinetics:“responder patients” showing a significant decrease of γ/δ T lymphocytes total …