The structures of gossypol complexes are extremely sensitive to the halogenomethane
present as the guest; eg changing the number of Cl atoms in chloromethane derivatives
changes the structure of the gossypol complex. The crystals of C 30 H 30 O 8· CH 2 Cl 2 are
monoclinic, space group C 2/c, a= 21.320 (4), b= 19.199 (6), c= 15.765 (2) Å, β= 113.05 (2)
o, V= 5916 (2) Å 3, Z= 8, D x= 1.35 g/cm 3, T= 295 K. The structure has been solved by direct
methods and refined to the final R value of 0.084 for 1828 reflections. In the structure H …

Gossypol, a biologically active compound with a wide spectrum of action (antiviral,
immunosuppressive, antifertile, etc.), is a unique compound in the sense of inclusion
complex formation. It gives clathrates with all 110 tested low-molecular organic substances.
For 80 clathrates single cyrstals have been obtained and their crystallographic parameters
have been determined. By the method of X-ray diffraction the structures of 30 inclusion
complexes has been solved. The extreme divergence of gossypol clathrate structures is …