3 天前 - … model organisms indicates that premature loss of meiotic cohesion is a major
determinant of age-induced … , a phenomenon known as the maternal age effect. Because cohesin …

7 天前 - … Using a mouse model of high fat diet (HFD)-induced obesity, the … mice and delayed
premature aging in a mouse model of progeria, opening new paths for the treatment of aging…

8 天前 - … for the development of a large animal model in sheep. Using CRISPR/Cas9 guides
55 bases downstream from the mutation site, we successfully induced deletions in sheep …

11 天前 - … , and causes accelerated ageing/frailty. Unfortunately, approaches to ameliorate
radiotherapy-induced late-effects are lacking and a paucity of appropriate model systems …

12 天前 - … for tumor growth in a mouse model of AITL, supporting … In preclinical studies,
ARV-393 induced rapid and robust … stasis or regression in xenograft models, supporting further …

14 天前 - … accelerates aging- and instability-induced cartilage degeneration in mice [34]. Despite
… Additionally, our surgical tail-looping mouse model to induce IVD degeneration does not …

15 天前 - … (ω-3 PUFAs) can ameliorate aging-induced intestinal mucosal barrier damage by …
mice are a senescence-accelerated mouse model with a short lifespan and accelerated aging …

15 天前 - … To tracing the subpopulation, a genetic mouse model with a GFP reporter was
generated by CRISPR/CAS9 gene editing. To characterize the subpopulation, cell division and …

15 天前 - … Conclusions : Our findings indicate a robust recruitment of activated neutrophils
to the outer retina in the NaIO3 model. The data also point to their rapid engagement of NETs …

15 天前 - … to establish pathophysiologically relevant disease models for the evaluation of
these … a human induced pluripotent stem cell (hiPSC)-derived retinal organoid (RO) model of …