[HTML][HTML] Induction of apoptosis and Fas receptor/Fas ligand expression by ischemia/reperfusion in cardiac myocytes requires serine 727 of the STAT-1 transcription …
A Stephanou, TM Scarabelli, BK Brar… - Journal of Biological …, 2001 - ASBMB
Previously we reported that ischemia results in apoptosis and is accompanied by
phosphorylation on Tyr-701 and increased expression and transcriptional activity of the
signal transducer and activator of transcription-1 (STAT-1). In the present study, we show
that exposure of cardiomyocytes to ischemia induced the phosphorylation of STAT-1 at
another site, Ser-727. Moreover, STAT-1 is critical for the induction of Fas receptor and Fas
ligand expression by ischemia/reperfusion (I/R). Transcriptional activation of Fas and FasL …
phosphorylation on Tyr-701 and increased expression and transcriptional activity of the
signal transducer and activator of transcription-1 (STAT-1). In the present study, we show
that exposure of cardiomyocytes to ischemia induced the phosphorylation of STAT-1 at
another site, Ser-727. Moreover, STAT-1 is critical for the induction of Fas receptor and Fas
ligand expression by ischemia/reperfusion (I/R). Transcriptional activation of Fas and FasL …
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