To achieve efficient degradation of pharmaceutical and personal care products (PPCPs), dual reaction centers ZnO@FePc photo-Fenton catalysts with high-speed electron transmission channel were designed through surface hydroxyl-induced assembly. In ZnO@FePc catalytic system, the photocatalysis center of ZnO and Fenton catalytic center of FePc were formed simultaneously. Concept and process for the control of hydroxyl groups to construct a dual reaction center ZnO@FePc photo-Fenton catalyst were verified ingeniously based on the density functional theory (DFT) analysis and experimental results. A series of catalysts, including ZIF-8 (400 ℃-N₂), FePc (400 ℃-N₂), ZIF-8 (400 ℃)-FePc (400 ℃) and ZnO@FePc were prepared and characterized by XRD, FTIR, TEM, BET, XPS, PL and DRS, respectively. The ZnO@FePc catalyst showed superior performance for the photo-Fenton degradation of ibuprofen, affording degradation rate larger than 90 % within just 10 min under simulateed sunlight. The excellent performance of ZnO@FePc catalyst is mainly attributed to the synergistic effect between dual reaction centers of ZnO@FePc. This work provides a novel method to construct dual reaction centers ZnO@FePc catalyst with efficient photo-generated electrons transmission link and to strengthen the synergistic effect of dual reaction centers.