Inhalable hydrophilic molecule-loaded liposomal dry powder formulations using supercritical CO2–assisted spray-drying

C Costa, B Nobre, AS Matos, AS Silva, T Casimiro… - Journal of CO2 …, 2021 - Elsevier
Liposomes are known to be one of the most promising drug delivery systems for carrying
and delivering biopharmaceuticals. Yet, both liposomes and biopharmaceuticals are
susceptible to destabilization during storage, and thus require cold supply and efficient
distribution chains. This drawback can be overcome, though, by converting liposomal
suspension into solid form dosage capable of administration via different routes, including
the lungs. In this work, we present a synergy between pharmaceutical and supercritical …
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