Inhibiting HLA-G restores IFN-γ and TNF-α producing T cell in pleural tuberculosis
Abstract Human Leukocyte Antigen-G (HLA-G), a non-classical, class Ib molecule, has been
shown to mediate immunoregulatory functions by inducing apoptosis, inhibits cytotoxicity
and differentiation by modulating cytokine secretion. Due to its immune-suppressive
function, it facilitates tolerance in feto-maternal interface and transplantation. In contrary, it
favours immune evasion of microbes and tumors by inhibiting immune and inflammatory
responses. In Tuberculosis (TB), we previously reported differential expression of HLA-G …
shown to mediate immunoregulatory functions by inducing apoptosis, inhibits cytotoxicity
and differentiation by modulating cytokine secretion. Due to its immune-suppressive
function, it facilitates tolerance in feto-maternal interface and transplantation. In contrary, it
favours immune evasion of microbes and tumors by inhibiting immune and inflammatory
responses. In Tuberculosis (TB), we previously reported differential expression of HLA-G …
Inhibiting HLA-G restores IFN-γ and TNF-α producing T cell in pleural tuberculosis.
AS Abhinav Saurabh, SC Sushmita Chakraborty… - 2018 - cabidigitallibrary.org
Abstract Human Leukocyte Antigen-G (HLA-G), a non-classical, class Ib molecule, has been
shown to mediate immunoregulatory functions by inducing apoptosis, inhibits cytotoxicity
and differentiation by modulating cytokine secretion. Due to its immune-suppressive
function, it facilitates tolerance in feto-maternal interface and transplantation. In contrary, it
favours immune evasion of microbes and tumors by inhibiting immune and inflammatory
responses. In Tuberculosis (TB), we previously reported differential expression of HLA-G …
shown to mediate immunoregulatory functions by inducing apoptosis, inhibits cytotoxicity
and differentiation by modulating cytokine secretion. Due to its immune-suppressive
function, it facilitates tolerance in feto-maternal interface and transplantation. In contrary, it
favours immune evasion of microbes and tumors by inhibiting immune and inflammatory
responses. In Tuberculosis (TB), we previously reported differential expression of HLA-G …
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