Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease
Abstract δ-secretase, also known as asparagine endopeptidase (AEP) or legumain, is a
lysosomal cysteine protease that cleaves both amyloid precursor protein (APP) and tau,
mediating the amyloid-β and tau pathology in Alzheimer's disease (AD). Here we report the
therapeutic effect of an orally bioactive and brain permeable δ-secretase inhibitor in mouse
models of AD. We performed a high-throughput screen and identified a non-toxic and
selective δ-secretase inhibitor, termed compound 11, that specifically blocks δ-secretase but …
lysosomal cysteine protease that cleaves both amyloid precursor protein (APP) and tau,
mediating the amyloid-β and tau pathology in Alzheimer's disease (AD). Here we report the
therapeutic effect of an orally bioactive and brain permeable δ-secretase inhibitor in mouse
models of AD. We performed a high-throughput screen and identified a non-toxic and
selective δ-secretase inhibitor, termed compound 11, that specifically blocks δ-secretase but …
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