Inhibition of lysosomal acid sphingomyelinase by agents which reverse multidrug resistance
An increasing body of evidence appears to implicate the lipid bilayer of multidrug resistant
(MDR) cells with P-glycoprotein activity. Several cationic amphiphilic drugs (CADs) have
been extensively described as modulators of MDR. These same agents are also known to
(1) inhibit lysosomal acid sphingomyelinase (ASmase), a phospholipid degrading enzyme,
and/or (2) induce phospholipidosis in animal tissues or cultured cell lines. In this report, we
randomly selected 17 CADs and evaluated their potency in modulating MDR in the murine …
(MDR) cells with P-glycoprotein activity. Several cationic amphiphilic drugs (CADs) have
been extensively described as modulators of MDR. These same agents are also known to
(1) inhibit lysosomal acid sphingomyelinase (ASmase), a phospholipid degrading enzyme,
and/or (2) induce phospholipidosis in animal tissues or cultured cell lines. In this report, we
randomly selected 17 CADs and evaluated their potency in modulating MDR in the murine …
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