[HTML][HTML] Inhibitory effects of Porphyromonas gingivalis fimbriae on interactions between extracellular matrix proteins and cellular integrins
Porphyromonas gingivalis is a predominant periodontal pathogen, whose fimbriae are
considered to be a major virulence factor, especially for bacterial adherence and invasion of
host cells. In the present study, we investigated the influence of fimbriae on the interactions
between αvβ3-and α5β1-integrins and their ligand extracellular matrix (ECM) proteins
(vitronectin and fibronectin), using human αvβ3-and α5β1-integrin-overexpressing CHO cell
lines (CHOαvβ3 and CHOα5β1, respectively). P. gingivalis was found to have significantly …
considered to be a major virulence factor, especially for bacterial adherence and invasion of
host cells. In the present study, we investigated the influence of fimbriae on the interactions
between αvβ3-and α5β1-integrins and their ligand extracellular matrix (ECM) proteins
(vitronectin and fibronectin), using human αvβ3-and α5β1-integrin-overexpressing CHO cell
lines (CHOαvβ3 and CHOα5β1, respectively). P. gingivalis was found to have significantly …
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