Insights into the lactonase mechanism of serum paraoxonase 1 (PON1): experimental and quantum mechanics/molecular mechanics (QM/MM) studies
Serum paraoxonase 1 (PON1) is a versatile enzyme for the hydrolysis of various substrates
(eg, lactones, phosphotriesters) and for the formation of a promising chemical platform γ-
valerolactone. Elucidation of the PON1-catalyzed lactonase reaction mechanism is very
important for understanding the enzyme function and for engineering this enzyme for
specific applications. Kinetic study and hybrid quantum mechanics/molecular mechanics
(QM/MM) method were used to investigate the PON1-catalyzed lactonase reaction of γ …
(eg, lactones, phosphotriesters) and for the formation of a promising chemical platform γ-
valerolactone. Elucidation of the PON1-catalyzed lactonase reaction mechanism is very
important for understanding the enzyme function and for engineering this enzyme for
specific applications. Kinetic study and hybrid quantum mechanics/molecular mechanics
(QM/MM) method were used to investigate the PON1-catalyzed lactonase reaction of γ …
[引用][C] Insights into the Lactonase Mechanism of Serum Paraoxonase 1 (PON1): Experimental and Quantum Mechanics/Molecular Mechanics (QM/MM) Studies
K Seonghoon, C Rakwoo, KY Hwan - 2015
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