INSIGHTS ON TRP CHANNELS FROM IN VIVO STUDIES IN DROSOPHILA
▪ Abstract Transient receptor potential (TRP) channels mediate responses in a large variety
of signaling mechanisms. Most studies on mammalian TRP channels rely on heterologous
expression, but their relevance to in vivo tissues is not entirely clear. In contrast, Drosophila
TRP and TRP-like (TRPL) channels allow direct analyses of in vivo function. In Drosophila
photoreceptors, activation of TRP and TRPL is mediated via the phosphoinositide cascade,
with both Ca2+ and diacylglycerol (DAG) essential for generating the light response. In …
of signaling mechanisms. Most studies on mammalian TRP channels rely on heterologous
expression, but their relevance to in vivo tissues is not entirely clear. In contrast, Drosophila
TRP and TRP-like (TRPL) channels allow direct analyses of in vivo function. In Drosophila
photoreceptors, activation of TRP and TRPL is mediated via the phosphoinositide cascade,
with both Ca2+ and diacylglycerol (DAG) essential for generating the light response. In …
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