Inspiratory muscle training in patients with heart failure and inspiratory muscle weakness: a randomized trial

P Dall'Ago, GRS Chiappa, H Guths, R Stein… - Journal of the American …, 2006 - jacc.org
P Dall'Ago, GRS Chiappa, H Guths, R Stein, JP Ribeiro
Journal of the American College of Cardiology, 2006jacc.org
Objectives: This study sought to evaluate the effects of inspiratory muscle training in
inspiratory muscle strength, as well as in functional capacity, ventilatory responses to
exercise, recovery oxygen uptake kinetics, and quality of life in patients with chronic heart
failure (CHF) and inspiratory muscle weakness. Background: Patients with CHF may have
reduced strength and endurance in inspiratory muscles, which may contribute to exercise
intolerance and is associated with a poor prognosis. Methods: Thirty-two patients with CHF …
Objectives
This study sought to evaluate the effects of inspiratory muscle training in inspiratory muscle strength, as well as in functional capacity, ventilatory responses to exercise, recovery oxygen uptake kinetics, and quality of life in patients with chronic heart failure (CHF) and inspiratory muscle weakness.
Background
Patients with CHF may have reduced strength and endurance in inspiratory muscles, which may contribute to exercise intolerance and is associated with a poor prognosis.
Methods
Thirty-two patients with CHF and weakness of inspiratory muscles (maximal inspiratory pressure [Pimax] <70% of predicted) were randomly assigned to a 12-week program of inspiratory muscle training (IMT, 16 patients) or to a placebo-inspiratory muscle training (P-IMT, 16 patients). The following measures were obtained before and after the program: Pimaxat rest and 10 min after maximal exercise; peak oxygen uptake, circulatory power, ventilatory oscillations, and oxygen kinetics during early recovery (V̇o2/t−slope); 6-min walk test; and quality of life scores.
Results
The IMT resulted in a 115% increment Pimax, 17% increase in peak oxygen uptake, and 19% increase in the 6-min walk distance. Likewise, circulatory power increased and ventilatory oscillations were reduced. The V̇o2/t−slope was improved during the recovery period, and quality of life scores improved.
Conclusions
In patients with CHF and inspiratory muscle weakness, IMT results in marked improvement in inspiratory muscle strength, as well as improvement in functional capacity, ventilatory response to exercise, recovery oxygen uptake kinetics, and quality of life.
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