Insulin-like growth factor-1 (IGF-1) is a potent neurotrophic factor that promotes the
proliferation, migration and differentiation of glial and neuronal cells. IGF-1 can also protect
neurons from undergoing apoptotic cell death. IGF-1 is produced by the choroid plexus,
located in the ventricles. Knowledge of embryonic CSF composition at different
developmental stages could be the key to understanding the behavior of neuroepithelial
cells (neural stem and progenitor cells). In this study, CSF was aspirated from the lateral …

Insulin like growth factor‐1 (IGF‐1) is ubiquitously expressed growth factor that has profound
effects on the growth and differentiation of many cell types and tissues, including cells of the
central nervous system (CNS). IGF‐1 is produced by a wide variety of cells and is found in
many biological fluids including cerebrospinal fluid (CSF). IGF‐1 plays important role during
CNS development and repair. IGF‐1 has broad range neuroprotective effects and is a
therapeutic candidate for Huntington's disease (HD). IGF‐1 protects striatal neurons from the …