Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation
Background—Atrial fibrillation (AF) affects> 30 million individuals worldwide and is
associated with an increased risk of stroke, heart failure, and death. AF is highly heritable,
yet the genetic basis for the arrhythmia remains incompletely understood. Methods and
Results—To identify new AF-related genes, we used a multifaceted approach, combining
large-scale genotyping in 2 ethnically distinct populations, cis-eQTL (expression quantitative
trait loci) mapping, and functional validation. Four novel loci were identified in individuals of …
associated with an increased risk of stroke, heart failure, and death. AF is highly heritable,
yet the genetic basis for the arrhythmia remains incompletely understood. Methods and
Results—To identify new AF-related genes, we used a multifaceted approach, combining
large-scale genotyping in 2 ethnically distinct populations, cis-eQTL (expression quantitative
trait loci) mapping, and functional validation. Four novel loci were identified in individuals of …
[PDF][PDF] Integrating Genetic, Transcriptional, and Functional Analyses to Identify 5 Novel Genes for Atrial Fibrillation
Background—Atrial fibrillation (AF) affects> 30 million individuals worldwide and is
associated with an increased risk of stroke, heart failure, and death. AF is highly heritable,
yet the genetic basis for the arrhythmia remains incompletely understood. Methods and
Results—To identify new AF-related genes, we used a multifaceted approach, combining
large-scale genotyping in 2 ethnically distinct populations, cis-eQTL (expression quantitative
trait loci) mapping, and functional validation. Four novel loci were identified in individuals of …
associated with an increased risk of stroke, heart failure, and death. AF is highly heritable,
yet the genetic basis for the arrhythmia remains incompletely understood. Methods and
Results—To identify new AF-related genes, we used a multifaceted approach, combining
large-scale genotyping in 2 ethnically distinct populations, cis-eQTL (expression quantitative
trait loci) mapping, and functional validation. Four novel loci were identified in individuals of …
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