Integration of tumor inflammation, cell proliferation, and traditional biomarkers improves prediction of immunotherapy resistance and response
Background Contemporary to the rapidly evolving landscape of cancer immunotherapy is
the equally changing understanding of immune tumor microenvironments (TMEs) which is
crucial to the success of these therapies. Their reliance on a robust host immune response
necessitates clinical grade measurements of immune TMEs at diagnosis. In this study, we
describe a stable tumor immunogenic profile describing immune TMEs in multiple tumor
types with ability to predict clinical benefit from immune checkpoint inhibitors (ICIs). Methods …
the equally changing understanding of immune tumor microenvironments (TMEs) which is
crucial to the success of these therapies. Their reliance on a robust host immune response
necessitates clinical grade measurements of immune TMEs at diagnosis. In this study, we
describe a stable tumor immunogenic profile describing immune TMEs in multiple tumor
types with ability to predict clinical benefit from immune checkpoint inhibitors (ICIs). Methods …
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