Integrin β3 regions controlling binding of murine mAb 7E3: Implications for the mechanism of integrin αIIbβ3 activation
A Artoni, JH Li, B Mitchell, J Ruan… - Proceedings of the …, 2004 - National Acad Sciences
Abciximab, a derivative of the murine mAb 7E3, protects against ischemic complications of
percutaneous coronary interventions by inhibiting ligand binding to the αIIbβ3 receptor. In
this study we identified regions on integrin β3 that control 7E3 binding. Murine/human amino
acid substitutions were created in two regions of the βA domain that previous studies found
to influence 7E3 binding: the C177–C184 loop and K125–N133. The T182N substitution
and a K125Q mutation reduced 7E3 binding to human β3 in complex with αIIb. The …
percutaneous coronary interventions by inhibiting ligand binding to the αIIbβ3 receptor. In
this study we identified regions on integrin β3 that control 7E3 binding. Murine/human amino
acid substitutions were created in two regions of the βA domain that previous studies found
to influence 7E3 binding: the C177–C184 loop and K125–N133. The T182N substitution
and a K125Q mutation reduced 7E3 binding to human β3 in complex with αIIb. The …
[PDF][PDF] Integrin 3 regions controlling binding of murine mAb 7E3: Implications for the mechanism of integrin IIb 3 activation
A Artoni, JH Li, B Mitchell, J Ruan, J Takagi… - PNAS, 2004 - projects.iq.harvard.edu
Abciximab, a derivative of the murine mAb 7E3, protects against ischemic complications of
percutaneous coronary interventions by inhibiting ligand binding to the IIb 3 receptor. In this
study we identified regions on integrin 3 that control 7E3 binding. Murine human amino acid
substitutions were created in two regions of the A domain that previous studies found to
influence 7E3 binding: the C177–C184 loop and K125–N133. The T182N substitution and a
K125Q mutation reduced 7E3 binding to human 3 in complex with IIb. The introduction of …
percutaneous coronary interventions by inhibiting ligand binding to the IIb 3 receptor. In this
study we identified regions on integrin 3 that control 7E3 binding. Murine human amino acid
substitutions were created in two regions of the A domain that previous studies found to
influence 7E3 binding: the C177–C184 loop and K125–N133. The T182N substitution and a
K125Q mutation reduced 7E3 binding to human 3 in complex with IIb. The introduction of …
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