Interaction of human α-synuclein and Parkinson's disease variants with phospholipids: structural analysis using site-directed mutagenesis
RJ Perrin, WS Woods, DF Clayton… - Journal of Biological …, 2000 - ASBMB
α-Synuclein has been centrally implicated in neurodegenerative disease, and a normal
function in developmental synaptic plasticity has been suggested by studies in songbirds. A
variety of observations suggest the protein partitions between membrane and cytosol, a
behavior apparently conferred by a conserved structural similarity to the exchangeable
apolipoproteins. Here we show that the capacity to bind lipids is broadly distributed across
exons 3, 4, and 5 (encoding residues 1–102). Binding to phosphatidylserine-containing …
function in developmental synaptic plasticity has been suggested by studies in songbirds. A
variety of observations suggest the protein partitions between membrane and cytosol, a
behavior apparently conferred by a conserved structural similarity to the exchangeable
apolipoproteins. Here we show that the capacity to bind lipids is broadly distributed across
exons 3, 4, and 5 (encoding residues 1–102). Binding to phosphatidylserine-containing …
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